Lancaster Boulevard Lancaster, a charter city in northern Los Angeles County, in the Antelope Valley of the western Mojave Desert in Southern California. Lancaster is part of a twin city complex with its southern neighbor Palmdale, and together they are the principal cities within the Antelope Valley region.Located approximately 70 miles north (via I-5 and SR 14) of downtown Los Angeles, and is near the Kern County line. It is separated from the Los Angeles Basin by the San Gabriel Mountains to the south, and from Bakersfield and the San Joaquin Valley by the Tehachapi Mountains to the north. There are still wide open spaces making it a great place for investing or building.